ABSTRACT
Objective@#To observe the differences in specific IgE of allergic diseases.@*Methods@#The allergens in 1 028 patients (including 606 cases of eczema/specific dermatitis, 319 Cases of urticaria, 103 cases of papular urticaria and prurigo) were detected by German Allergy Screen Immune mark method.@*Results@#There were statistically significant differences (P<0.05) in the positive rate of allergens among the four allergic diseases, including Penicillium notatum/ Piptocephalis/ aspergillus fumigatus/aspergillus niger/Alternaria (χ2=6.663), milk (χ2=10.320) and cashew nut (χ2=14.325); The common allergen in <1-year-old group was cat dander (22.75%), egg white (35.93%); The common allergen in 1 to 3 years old group was dog dander (22.17%), milk (61.82%) and crab (3.45%). The common allergen in>3-year-old group was dust mite (10.77%), cockroach (3.52%), Penicillium notatum/Piptocephalis/ aspergillus fumigatus/aspergillus niger/Alternaria (21.32%), Short ragweed/artemisia/Humulus scandens/quinoa (14.73%). The positive rate of specific IgE against house dust in the third quarter was the highest (17.78%) and the difference was statistically significant (χ2=14.443, P=0.002). Among the statistically significant difference in the positive rate of specific IgE between eczema/atopic dermatitis in different age groups (χ2=10.204, P=0.006), the positive rate in the group of 1 to 3 years was the highest.@*Conclusions@#Different diseases, ages, and seasonal specific allergens are different, individualized treatment can be carried out according to disease types, ages and seasons.
ABSTRACT
Objective To observe the differences in specific IgE of allergic diseases.Methods The allergens in 1 028 patients (including 606 cases of eczema/specific dermatitis,319 Cases of urticaria,103 cases of papular urticaria and prurigo) were detected by German Allergy Screen Immune mark method.Results There were statistically significant differences (P ＜ 0.05) in the positive rate of allergens among the four allergic diseases,including Penicillium notatum/ Piptocephalis/ aspergillus fumigatus/aspergillus niger/Alternaria (x2 =6.663),milk (x2 =10.320) and cashew nut (x2 =14.325);The common allergen in ＜ 1-year-old group was cat dander (22.75％),egg white (35.93％);The common allergen in 1 to 3 years old group was dog dander (22.17％),milk (61.82％) and crab (3.45％).The common allergen in ＞ 3-year-old group was dust mite (10.77％),cockroach (3.52％),Penicillium notatum/Piptocephalis/aspergillus fumigatus/aspergillus niger/Altemaria (21.32％),Short ragweed/artemisia/Humulus scandens/quinoa (14.73％).The positive rate of specific IgE against house dust in the third quarter was the highest (17.78％) and the difference was statistically significant (x2 =14.443,P =0.002).Among the statistically significant difference in the positive rate of specific IgE between eczema/atopic dermatitis in different age groups (x2 =10.204,P =0.006),the positive rate in the group of 1 to 3 years was the highest.Conclusions Different diseases,ages,and seasonal specific allergens are different,individualized treatment can be carried out according to disease types,ages and seasons.
ABSTRACT
Objective To detect the serum level of vitamin D in infants with atopic dermatitis (AD),and to investigate the relationship between the serum level of vitamin D and severity of AD in infants.Methods Clinical data were collected from patients with moderate to severe AD (AD group)through a questionnaire survey in Children's Hospital of Shanxi from February to April in 2016,and the severity of AD was evaluated by the SCORing atopic dermatitis (SCORAD) score.A total of 95 health checkup examinees served as the control group.Enzyme-linked immunosorbent assay (ELISA)was performed to detect the serum level of 25 (OH) D3 in the AD group and control group,as well as the total serum IgE level in the AD group.Blood cell analyzer was used to determine the proportion of blood eosinophils in the AD group.Results A total of 97 patients with AD were enrolled into the study,including 43 (44.3 ％) patients with moderate AD and 54 (55.7％) patients with severe AD.The serum level of 25 (OH) D3 was significantly lower in the AD group than in the healthy control group ([66.71 ± 21.07] nmol/L vs.[85.43 ± 14.87] nmol/L,P ＜ 0.01),as well as in the patients with severe AD than in the patients with moderate AD ([47.54 ± 29.36] nmol/L vs.[63.89 ± 26.67] nmol/L,P =0.006).The proportion of blood eosinophils was significantly higher in the severe AD group than in the moderate AD group (0.124 ± 0.094 vs.0.061 ± 0.060,P ＜ 0.001).There was no significant difference in the total serum IgE level between the moderate AD group and severe AD group (P =0.375).Among the patients with AD,the serum level of 25 (OH) D3 was negatively correlated with the proportion of blood eosinophils (r =-0.336,P ＜ 0.05),but there was no correlation between the serum level of 25 (OH)D3 and total serum IgE level (r =-0.174,P ＞ 0.05).The serum level of 25 (OH)D3 was significantly associated with breastfeeding and vitamin D supplementation (P ＜ 0.05),but unrelated to age,gender,course of disease and acute exudative phase (all P ＞ 0.05).Conclusion The serum level of 25 (OH) D3 is evidently decreased in infants with AD,and vitamin D deficiency is closely related to the severity of AD in infancy.